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Engineered nanotools for advanced cell therapies

Type of activity
Competitive project
Acronym
CytoNanoHeal
Funding entity
MIN DE ECONOMIA Y COMPETITIVIDAD
Funding entity code
PCIN-2015-113
Amount
150.000,00 €
Start date
2015-12-01
End date
2019-05-31
Keywords
adipose, biological therapies, citoquinas, cytokines, células madre, glycosaminoglycan nanotemplates, nanofibras de hidrogeles supramoleculares, nanofibrous supramolecular hydrogels, nanoparticulas de glicosaminoglican, osteoarthritis, osteoartritis, stem cells, tejido adiposo, terapias biológicas
Abstract
CytoNanoHeal aims at engineering of delivery systems that enable long-term efficiency of biological entities
in cell-based therapies. The cell-matched rationale of the novel injectable supramolecular nanofibrous
hydrogels based on self-assembling peptide amphiphiles, complemented with glycosaminoglycan
nanoparticle (GAG-NPs) templates, will allow long-term efficiency of various biological therapies.
As a proof-of-concept in regenerative medicine, the nanoconstructs will be used to provide optimal spatial
and functional support for bioentities in a combined therapy for osteoarthritis (OA) comprising:
- Cytokines for retarding the disease and pain relief, and
- Stem cells for cartilage regeneration.
A patent-protected anti-inflammatory cytokine cocktail (ACC), formulated from human blood plasma will be
injected together with in-situ gelating peptide amphiphiles and GAG-NPs into the OAaffected joints to delay the
disease progression and boost the anabolic pathways for recovery of the damaged cartilage. The ACC is a
synergistic combination of bioentities that inhibit the chronicity of OA pro-inflammatory factors. The novel
delivery systems will be used to protect the unstable cytokines and boost the therapeutic effect. Additionally,
mesenchymal stem cells from adipose tissue (ASCs) will be supplied using the engineered nanoconstructs to
initiate the cartilage regeneration by differentiation of ASCs into chondrocytes.
UPC will play the role as coordinator of the European project. UPC is the last responsible for managing
CytoNanoHeal by monitoring the scientific, financial and the dissemination activities of the results of the
consortium. UPC will also be responsible for the tasks required to fulfill the following specific objectives.
- Development and characterization of GAG-NPs templates to improve the efficiency of the ACC
cocktails and stimulate the cellular interactions promoting the cartilage regeneration.
- Characterize the injectable supramolecular hydrogels efficiency in order to stabilize ASC and
other, capable of housing several biological entities.
- Study the efficacy vs. toxicity balance and the biocompatibility of the constructs.
Scope
Adm. Estat
Plan
Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016
Call year
2015
Funcding program
Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad
Funding call
Acciones de Programación Conjunta Internacional
Grant institution
Agencia Estatal De Investigacion

Participants