Loading...
Loading...

Go to the content (press return)

Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes

Author
Llacher Alsina, Anna Pilar; Vallmitjana, A.; Benitez, R.; Montiel, J.; Cinca, J.
Type of activity
Journal article
Journal
Basic research in cardiology
Date of publication
2016-01-01
Volume
111
First page
1
Last page
1
DOI
https://doi.org/10.1007/s00395-015-0525-2 Open in new window
Repository
http://hdl.handle.net/2117/82603 Open in new window
Abstract
© 2015, Springer-Verlag Berlin Heidelberg. Atrial fibrillation (AF) has been associated with increased spontaneous calcium release from the sarcoplasmic reticulum and linked to increased adenosine A2A receptor (A2AR) expression and activation. Here we tested whether this may favor atrial arrhythmogenesis by promoting beat-to-beat alternation and irregularity. Patch-clamp and confocal calcium imaging was used to measure the beat-to-beat response of the calcium current and transient in human atri...
Citation
Llacher Alsina, Anna Pilar, Vallmitjana, A., Benitez, R., Montiel, J., Cinca, J. Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes. "Basic research in cardiology", 01 Gener 2016, vol. 111, p. 1.
Keywords
Adenosine receptor, Atrial myocyte, Electrophysiology, Sarcoplasmic reticulum, l-Type calcium current
Group of research
ANCORA - Anàlisi i control del ritme cardíac
B2SLab - Bioinformatics and Biomedical Signals Laboratory
CREB - Biomedical Engineering Research Centre

Participants

  • Llacher Alsina, Anna Pilar  (author)
  • Vallmitjana Lees, Alexander  (author)
  • Benitez Iglesias, Raul  (author)
  • Montiel Dacosta, José Antonio  (author)
  • Cinca Cuscullola, Juan Maria  (author)

Attachments