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Functional effects of chronic paroxetine versus placebo on the fear, stress and anxiety brain circuit in social anxiety disorder: initial validation of an imaging protocol for drug discovery

Author
Gimenez, M.; Ortiz, H.; Soriano-Mas, C.
Type of activity
Journal article
Journal
European neuropsychopharmacology
Date of publication
2014
Volume
24
Number
1
First page
105
Last page
116
DOI
https://doi.org/10.1016/j.euroneuro.2013.09.004 Open in new window
URL
http://www.sciencedirect.com/science/article/pii/S0924977X13002654 Open in new window
Abstract
Recent studies suggest that pharmacologic effects of anxiolytic agents can be mapped as functional changes in the fear, stress and anxiety brain circuit. In this work we investigated the effects of a standard treatment, paroxetine (20 mg/day), in subjects with Social Anxiety Disorder (SAD) versus placebo using different fMRI paradigms. The fMRI sessions, performed before and after the treatment, consisted of a public exposition of recorded performance task (PERPT), an emotional face processing t...
Keywords
Anxiety, Placebo, Public speaking test, Randomized clinical trial, Resting state, Social emotional stimuli, fMRI
Group of research
GIIP - Project Design, Sustainability and Communication Research Group

Participants