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Ion-doping as a strategy to modulate hydroxyapatite nanoparticle internalization

Author
Zhao, Z.; Español, M.; Guillem-Marti, J.; Kempf, D.; Diez-Escudero, A.; Ginebra, M.P.
Type of activity
Journal article
Journal
Nanoscale
Date of publication
2016-01-21
Volume
8
Number
3
First page
1595
Last page
1607
DOI
https://doi.org/10.1039/c5nr05262a Open in new window
Repository
http://hdl.handle.net/2117/83440 Open in new window
URL
http://pubs.rsc.org/en/Content/ArticleLanding/2016/NR/C5NR05262A#!divAbstract Open in new window
Abstract
Although it is widely acknowledged that ionic substitutions on bulk hydroxyapatite substrates have a strong impact on their biological performance, little is known of their effect on nanoparticles (NPs) especially when used for gene transfection or drug delivery. The fact that NPs would be internalized poses many questions but also opens up many new possibilities. The objective of the present work is to synthesize and assess the effect of a series of hydroxyapatite-like (HA) NPs doped with vario...
Citation
Zhao, Z., Español, M., Guillem-Marti, J., Kempf, D., Diez, A., Ginebra, M.P. Ion-doping as a strategy to modulate hydroxyapatite nanoparticle internalization. "Nanoscale", 2016, vol. 8, núm. 3, p. 1595-1607.
Group of research
BBT - Biomaterials, Biomechanics and Tissue Engineering
CREB - Biomedical Engineering Research Centre
CRnE - Barcelona Research Center in Multiscale Science and Engineering

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