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Selecting the primary endpoint in a randomized clinical trial: the ARE method

Author
Plana-Ripoll, O.; Gómez Melis, Guadalupe
Type of activity
Journal article
Journal
Journal of biopharmaceutical statistics
Date of publication
2016
Volume
26
Number
5
First page
880
Last page
898
DOI
https://doi.org/10.1080/10543406.2015.1094808 Open in new window
Repository
http://hdl.handle.net/2117/102360 Open in new window
URL
http://www-tandfonline-com.recursos.biblioteca.upc.edu/doi/full/10.1080/10543406.2015.1094808 Open in new window
Abstract
The decision on the primary endpoint in a randomized clinical trial is of paramount importance and the combination of several endpoints might be a reasonable choice. Gómez and Lagakos (2013) have developed a method that quantifies how much more efficient it could be to use a composite instead of an individual relevant endpoint. From the information provided by the frequencies of observing the component endpoints in the control group and by the relative treatment effects on each individual endpo...
Citation
Plana-Ripoll, O., Gomez, G. Selecting the primary endpoint in a randomized clinical trial: the ARE method. "Journal of biopharmaceutical statistics", 2016, vol. 26, núm. 5, p. 880-898.
Keywords
Asymptotic relative efficiency, composite endpoint, copulas, logrank, randomized clinical trial
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

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