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Micro-pieces constituted by biodegradable poly(ester amide)s loaded with bacteriophages and biomolecules susceptible to denaturation processes: Biomedical applications

Total activity: 13
Type of activity
Competitive project
Funding entity
Funding entity code
102.850,00 €
Start date
End date
The main goal of the project is the development of micropieces for biomedical applications, taking into account three main aspects:
1. Synthesis of new biodegradable polymers that can be used as matrices. Poly(ester amide)s and poly(ester urea)s with natural alfa-amino acid or polyamine units will be considered with both, a regular or blocky microstructure. Polymers are designed to be
biodegradable, being considered a wide variety of structures and compositions for their use in different fields: polycationic polymers that
favor adsorption processes; Polymers with an amphiphilic nature to favour encapsulation processes; Easily crosslinkable polymers to be
used as hydrogels.
2. Study of specific applications in the field of biomedicine that could render new materials with an added value to provide clear benefits in
the field of health. In particular it will be considered: a) Incorporation of bacteriophages as an alternative to the use of antibiotics; b)
Incorporation of biomolecules with a specific activity against degenerative neurological diseases (e.g. chaperones); c) Preparation of
hybrid materials that combine biodegradable polymers and conductive polymers in order to enhance for example the stimulation of cell
growth; d) Incorporation of whiskers of chitin as reinforcing material. e) Incorporation of hydroxyapatite nanoparticles as a means for
encapsulating DNA and drugs that could enhance the necrosis of cancer cells.
3. In the third section we will focus on the development of a new micro-molding technology based on the use of ultrasounds as an energy
source. Different topics will be evaluated:
a) The ability to process the new designed biodegradable polymers; b) The ability to encapsulate molecules with pharmacological activity;
c) The ability to prepare nanocomposites that incorporate HAp particles and chitin; d) The ability to prepare homogeneous mixtures of
polymers with very different characteristics (e.g. conductive and biodegradable polymers); e) The technical possibilities to prepare
scaffolds with a regular pore distribution by the incorporation of particles readily soluble in aqueous media.
New materials will also be processed by other more conventional techniques such as electrospinning. Specifically, different approaches
have been proposed: a) Processing of the selected biodegradable polymers with other soluble polymers in aqueous media (e.g. coaxial
electrospinning and co-electrospinning) and the study of miniemulsion processes. Both methods are considered to enable the
encapsulation of biomolecules that are susceptible to be denatured in organic media; b) Processing of hybrid materials containing
biodegradable polymers and conducting polymers, and hybrid composites constituted by biodegradable polymers and inorganic
compounds; c) Preparation of three-dimensional scaffolds by the combination of successive layers of electrospun fibers and hydrogels with
the encapsulated active compounds.
The project has had support from some companies since partnerships have been established with B. Braun Surgical S.A. and Minoryx
Therapeutics to develop the proposed biomedical applications and with Ultrasion S..L. and the Eurecat Foundation for the development of
the ultrasound micro-molding technology.
andamios temporales, biodegradación, biodegradation, biomedicina, biomedicine, electrohilado, electrospinning, hidrogeles, hydrogels, micro-processing, microprocesado, poliesteramidas, poly(ester amide)s, scaffolds, ultrasonidos, ultrasounds
Adm. Estat
Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016
Resoluton year
Funcding program
Programa Estatal de I+D+i Orientada a los Retos de la Sociedad
Funding call
Retos de Investigación: Proyectos de I+D+i
Grant institution
Gobierno De España. Ministerio De Economía Y Competitividad, Mineco


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