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Novel bioprinting strategies for bone regeneration and cancer therapies

Total activity: 1
Type of activity
Competitive project
Funding entity
Funding entity code
338.800,00 €
Start date
End date
The main objective of PRINT4LIFE is to develop scaffolds for the treatment of complex critical size bone defects in a patient-specific
manner, able to respond to the challenging needs of patients affected by complex situations derived from osteoporosis, osteomyelitis or
cancer. PRINT4LIFE proposes a combinatorial approach using the most recent progresses in 3D ink-jet printing technology together with
advanced therapies such as drug delivery and tissue engineering, and covers from the development of bioinks to the direct printing of
customized scaffolds, including the characterisation of their physical and chemical properties and their pre-clinical evaluation. The project
1) The design of bioinks with different compositions and biological activities capable of rendering the cues needed to enhance bone
regeneration, including biomimetic self-setting ceramic inks, and hydrogels containing or not mineral nanoparticles. The following
challenges will be addressed: i) to develop biomimetic ceramic inks able to harden at low temperature, without need of sintering, in a
clinically acceptable period of time, with high resolution, stability and reproducibility; ii) to develop multifunctional hydrogel bioinks
endorsed with particular biological functionalities through incorporation of growth factors, ions and nanoparticles to enhance bone
regeneration. In this sense, a particular challenge that will be addressed is to exploit the lethal effects of highly reactive species generated
by APP in liquid media on bone cancer cells, to develop hydrogel inks acting as vehicles to deliver APP species and if required, coadjuvant
low doses of chemotherapeutic drugs.
2) The development of 3D ink-jet printed scaffolds with complex 3D architectures and a tailored local distribution of various biological
components, i.e. biologically active molecules and cells. Specifically, we seek to produce: i) on-site (in-hospital) 3D-printed ready-to use biomimetic ceramic scaffolds, printed following the geometry of the bone defect obtained by CT or NMR; ii)
scaffolds with intercalated ceramic/hydrogel structures, which will allow tuning the mechanical properties and the osteogenic capacity of
the 3D structures; iii) core-shell structures for dual release and cell encapsulation. Particularly relevant will be the development of prevascularised
3D scaffolds through simultaneous printing of biomimetic ceramic strands alternated with tubular hydrogel structures including
endothelial cells that will act as pre-vascularised strands.
3D printing, Materials engineering; Biomaterials; Plasma; Calcium Phosphates; Hydrogels; Tissue Engineering; Bone cancer, biomateriales, cáncer de hueso, fosfatos de calcio, hidrogeles, impresión 3D, ingeniería de materiales, ingeniería de tejidos, plasma
Adm. Estat
Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016
Resoluton year
Funcding program
Programa Estatal de I+D+i Orientada a los Retos de la Sociedad
Funding call
Retos de Investigación: Proyectos de I+D+i
Grant institution
Gobierno De España. Ministerio De Economía Y Competitividad, Mineco


Scientific and technological production

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