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Advanced osteoinductive and antimicrobial coatings to engineer biomaterials for improving osteointegration in osteoporotic and diabetic pathologies

Total activity: 6
Type of activity
Competitive project
Acronym
ADVANTOSS
Funding entity
MIN DE ECONOMIA Y COMPETITIVIDAD
Funding entity code
MAT2015-67183-R
Amount
121.000,00 €
Start date
2016-01-01
End date
2019-06-30
Keywords
biofuncionalizacion, biofunctionalization, biomaterial, bone, diabetes, diabetis, hueso, osseiointegration, osteointegración, osteoporosis, ostheoporosis, poroso, porous, titanio, titanium
Abstract
This project is focused on adding value to the emerging and relevant fields of tissue engineering and regenerative medicine. Nowadays,
reparative and regenerative medicine are of paramount importance due to the high rise in life expectancy and the increasing number of
diseases associated to populaton ageing. In this regard, the limited biological performance of current bone implants, such as joint
replacement prostheses (i.e. hip and knee implants), bone screws and spinal fusion systems, represents an ever-growing socioeconomic
burden in Europe and the United States. The mid- and long-term success of implant materials for bone relies on a successful integration of
the material with surrounding bone after the implantation surgery. However, despite bones natural capacity for healing, traumatic injuries
and several pathological diseases such as cancer, periimplant infections, osteoporosis and diabetes can impair normal bone functions and
compromise an optimal osseointegration.
Thus, the main goal of this research project is to develop novel coatings with osteoinductive and antimicrobial properties to engineer
biomaterials with improved osteointegrative capacity. In particular, this proposal focuses on clinically compromised scenarios, where
osseointegration is seriously challenged: osteoporotic and diabetic patients. Such goal will be addressed following two approaches:
1) Porous titanium alloys with optimal biomechanical properties will promote faster rates of bone growth through the interconnected
porosity, better vascularization and therefore accelerated osseointegration compared to classical implant materials.
2) The use of coatings that install osteoinductive properties (i.e. enhanced osteoblast adhesion and osteogenic differentiation) and
antibacterial properties will improve the bioactivity of the implant material while reducing the extent of bacterial colonization. Moreover, the
use of drug-encapsulating polymeric systems allows the use of drugs for a specific pathology.
These coatings will be based on i) peptide-based multifunctional platforms with cell adhesive, osteogenic and/or antibacterial potential; ii)
recombinant protein fragments that promote cell adhesion and osteogenic differentiation; iii) polymeric systems based on nanocapsules or
hydrogel coatings with the capacity to encapsulate diverse drugs (i.e. antibiotics or drugs that regulate mitochondrial function - Metformin
and Nifedipine); iv) functionalized antifouling coatings, which combine the repellent properties of polymers like PEG with antibacterial
peptides.
The biofunctionalized materials will be carefully characterized by means of a wide range of mechanical and physicochemical methods, in
vitro studies of cell response (adhesion, proliferation and differentiation), mitochondrial function and antibacterial properties. The in vivo
evaluation of the most promising biomaterials will be performed in healthy, osteoporotic and diabetic Wistar rats, and focus on the capacity
of the materials to support and improve osseointegration.
This proposal falls within the main strategies described in the PLAN ESTATAL DE INVESTIGACIÓN CIENTÍFICA Y TÉCNICA Y DE
INNOVACIÓN (2013-2016) of the Ministerio de Economía y Competitividad and the EU strategic vision of the H2020 programme,
addressing the Challenge of Health, demographic change and well-being (Reto 1), by developing a technologically-based advanced
therapy for an existing challenge in healthcare.
Scope
Adm. Estat
Plan
Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016
Call year
2016
Funcding program
Programa Estatal de I+D+i Orientada a los Retos de la Sociedad
Funding call
Retos de Investigación: Proyectos de I+D+i
Grant institution
Gobierno De España. Ministerio De Economía Y Competitividad, Mineco

Participants

Scientific and technological production

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