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Advanced osteoinductive and antimicrobial coatings to engineer biomaterials for improving osteointegration in osteoporotic and diabetic pathologies

Total activity: 9
Type of activity
Competitive project
Funding entity
Funding entity code
121.000,00 €
Start date
End date
This project is focused on adding value to the emerging and relevant fields of tissue engineering and regenerative medicine. Nowadays, reparative and regenerative medicine are of paramount importance due to the high rise in life expectancy and the increasing number of diseases associated to populaton ageing. In this regard, the limited biological performance of current bone implants, such as joint replacement prostheses (i.e. hip and knee implants), bone screws and spinal fusion systems, represents an ever-growing socioeconomic burden in Europe and the United States. The mid- and long-term success of implant materials for bone relies on a successful integration of
the material with surrounding bone after the implantation surgery. However, despite bones natural capacity for healing, traumatic injuries and several pathological diseases such as cancer, periimplant infections, osteoporosis and diabetes can impair normal bone functions and compromise an optimal osseointegration.
Thus, the main goal of this research project is to develop novel coatings with osteoinductive and antimicrobial properties to engineer biomaterials with improved osteointegrative capacity. In particular, this proposal focuses on clinically compromised scenarios, where osseointegration is seriously challenged: osteoporotic and diabetic patients. Such goal will be addressed following two approaches:
1) Porous titanium alloys with optimal biomechanical properties will promote faster rates of bone growth through the interconnected porosity, better vascularization and therefore accelerated osseointegration compared to classical implant materials.
2) The use of coatings that install osteoinductive properties (i.e. enhanced osteoblast adhesion and osteogenic differentiation) and antibacterial properties will improve the bioactivity of the implant material while reducing the extent of bacterial colonization. Moreover, the use of drug-encapsulating polymeric systems allows the use of drugs for a specific pathology.
These coatings will be based on i) peptide-based multifunctional platforms with cell adhesive, osteogenic and/or antibacterial potential; ii) recombinant protein fragments that promote cell adhesion and osteogenic differentiation; iii) polymeric systems based on nanocapsules or hydrogel coatings with the capacity to encapsulate diverse drugs (i.e. antibiotics or drugs that regulate mitochondrial function - Metformin and Nifedipine); iv) functionalized antifouling coatings, which combine the repellent properties of polymers like PEG with antibacterial peptides.
The biofunctionalized materials will be carefully characterized by means of a wide range of mechanical and physicochemical methods, in vitro studies of cell response (adhesion, proliferation and differentiation), mitochondrial function and antibacterial properties. The in vivo evaluation of the most promising biomaterials will be performed in healthy, osteoporotic and diabetic Wistar rats, and focus on the capacity of the materials to support and improve osseointegration.
This proposal falls within the main strategies described in the PLAN ESTATAL DE INVESTIGACIÓN CIENTÍFICA Y TÉCNICA Y DE INNOVACIÓN (2013-2016) of the Ministerio de Economía y Competitividad and the EU strategic vision of the H2020 programme, addressing the Challenge of Health, demographic change and well-being (Reto 1), by developing a technologically-based advanced therapy for an existing challenge in healthcare.
biofuncionalizacion, biofunctionalization, biomaterial, bone, diabetes, diabetis, hueso, osseiointegration, osteointegración, osteoporosis, ostheoporosis, poroso, porous, titanio, titanium
Adm. Estat
Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016
Resoluton year
Funcding program
Programa Estatal de I+D+i Orientada a los Retos de la Sociedad
Funding call
Retos de Investigación: Proyectos de I+D+i
Grant institution
Gobierno De España. Ministerio De Economía Y Competitividad, Mineco


Scientific and technological production

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