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Glucocorticoid receptors, brain-derived neurotrophic factor, serotonin and dopamine neurotransmission are associated with interferon-induced depression

Author
Udina, M.; Navines, R.; Egmond, E.; Oriolo, G.; Langohr, K.; Giménez, D.; Valdés, M.; Gomez, E.; Grande, I.; Gratacos, M.; Kapczinski, F.; Artigas, F.; Vieta, E.; Solà, R.; Martin-Santos, R.
Type of activity
Journal article
Journal
International journal of neuropsychopharmacology
Date of publication
2016-12-30
Volume
19
Number
4
First page
1
Last page
12
DOI
https://doi.org/10.1093/ijnp/pyv135 Open in new window
Project funding
Métodos avanzados en estudios de seguimiento: diseño de ensayos clínicos, datos longitudinales y censura en un intervalo
Repository
http://hdl.handle.net/2117/100658 Open in new window
URL
http://ijnp.oxfordjournals.org/content/19/4/pyv135 Open in new window
Abstract
Background: The role of inflammation in mood disorders has received increased attention. There is substantial evidence that cytokine therapies, such as interferon alpha (IFN-alpha), can induce depressive symptoms. Indeed, proinflammatory cytokines change brain function in several ways, such as altering neurotransmitters, the glucocorticoid axis, and apoptotic mechanisms. This study aimed to evaluate the impact on mood of initiating IFN-alpha and ribavirin treatment in a cohort of patients with c...
Citation
Udina, M., Navines, R., Egmond, E., Oriolo, G., Langohr, K., Giménez, D., Valdés, M., Gomez, E., Grande, I., Gratacos, M., Kapczinski, F., Artigas, F., Vieta, E., Sola, R., Martin, R. Glucocorticoid receptors, brain-derived neurotrophic factor, serotonin and dopamine neurotransmission are associated with interferon-induced depression. "International journal of neuropsychopharmacology", 30 Desembre 2016, vol. 19, núm. 4, p. 1-12.
Keywords
5HT1A, COMT, GCR1, depression, genetic, hepatitis C, inflammation pathways, personality traits, risk factors
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Udina, Marc  (author)
  • Navinés, Ricard  (author)
  • Egmond, E.  (author)
  • Oriolo, G.  (author)
  • Langohr, Klaus  (author)
  • Giménez, Dolors  (author)
  • Valdés, M.  (author)
  • Gómez Gil, E.  (author)
  • Grande, I.  (author)
  • Gratacos, M.  (author)
  • Kapczinski, F.  (author)
  • Artigas, F.  (author)
  • Vieta, E.  (author)
  • Solà, Ricard  (author)
  • Martin Santos, Rocío  (author)

Attachments