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Design of calcium phosphate scaffolds with controlled simvastatin release by plasma polymerisation

Author
Canal, C.; Khurana, K.; Gallinetti, S.; Bhatt, S.; Pulpytel, J.; Arefi, F.; Ginebra, M.P.
Type of activity
Journal article
Journal
Polymer
Date of publication
2016-06-01
Volume
92
First page
170
Last page
178
DOI
https://doi.org/10.1016/j.polymer.2016.03.069 Open in new window
Project funding
Novel bioprinting strategies for bone regeneration and cancer therapies
Repository
http://hdl.handle.net/2117/89972 Open in new window
URL
http://www.sciencedirect.com/science/article/pii/S0032386116302166 Open in new window
Abstract
Calcium Phosphates (CaPs) have excellent bone regeneration capacity, and their combination with specific drugs is of interest because it allows adding new functionalities. In CaPs, drug release is mainly driven by diffusion, which is strongly affected by the porosity of the matrix and the drug-material interaction. Therefore, it is very difficult to tune their drug release properties beyond their intrinsic properties. Furthermore, when the CaPs are designed as scaffolds, the increased complexity...
Citation
Canal, C., Khurana, K., Gallinetti, S., Bhatt, S., Pulpytel, J., Arefi, F., Ginebra, M.P. Design of calcium phosphate scaffolds with controlled simvastatin release by plasma polymerisation. "Polymer", 1 Juny 2016, vol. 92, p. 170-178.
Keywords
Calcium phosphate, Cements, Ceramics, Controlled drug release, PCL-PEG plasma polymerisation, Scaffolds, behavior, cements, drug-delivery, in-vitro, polypropylene, statins
Group of research
BBT - Biomaterials, Biomechanics and Tissue Engineering
CREB - Biomedical Engineering Research Centre
CRnE - Barcelona Research Center in Multiscale Science and Engineering

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