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Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

Author
De la Torre, R.; de Sola, S.; Hernández, G.; Farré, M.; Langohr, K.; Cuenca, A.; Xicota, L.; Janel, N.; Gonzalo Sanchez-Benavides; Blehaut, H.; del Hoyo, L.; Benejam, B.; Blanco,-Hinojo L.; Videla, S.; Dierssen, M.
Type of activity
Journal article
Journal
Lancet neurology
Date of publication
2016-07-01
Volume
15
Number
8
First page
801
Last page
810
DOI
https://doi.org/10.1016/S1474-4422(16)30034-5 Open in new window
Repository
http://hdl.handle.net/2117/100655 Open in new window
URL
http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(16)30034-5/abstract Open in new window
Abstract
Background Early cognitive intervention is the only routine therapeutic approach used for amelioration of intellectual deficits in individuals with Down's syndrome, but its effects are limited. We hypothesised that administration of a green tea extract containing epigallocatechin-3-gallate (EGCG) would improve the effects of non-pharmacological cognitive rehabilitation in young adults with Down's syndrome.; Methods We enrolled adults (aged 16-34 years) with Down's syndrome from outpatient settin...
Citation
De la Torre, R., de Sola, S., Hernández, G., Farré, M., Langohr, K., Cuenca, A., Xicota, L., Janel, N., Gonzalo Sanchez-Benavides, Blehaut, H., del Hoyo, L., Benejam, B., Blanco,-Hinojo L., Videla, S., Dierssen, M. Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial. "Lancet neurology", 1 Juliol 2016, vol. 15, núm. 8, p. 801-810.
Keywords
Brain, DYRK1A, Deficits, Expression, Green tea polyphenols, Kinase, Metabolism, Mouse models, Rescue
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • De la Torre Fornell, Rafael  (author)
  • de Sola Llopis, Susana  (author)
  • Hernández, Gimena  (author)
  • Farré, Magí  (author)
  • Langohr, Klaus  (author)
  • Cuenca Royo, Aida  (author)
  • Xicota, Laura  (author)
  • Janel, Nathalie  (author)
  • Sánchez Benavides, Gonzalo  (author)
  • Blehaut, Henri  (author)
  • del Hoyo, Laura  (author)
  • Benejam, Bessy  (author)
  • Blanco Hinojo, Laura  (author)
  • Videla, Sebastià  (author)
  • Dierssen, Mara  (author)

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