Carregant...
Carregant...

Vés al contingut (premeu Retorn)

CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis

Autor
Cano, O.; Céspedes, M. V.; Unzueta, U.; Roldan, M.; Cubarsi, R.; Vazquez, E.; García, E.; Villaverde, A.
Tipus d'activitat
Article en revista
Revista
Nanomedicine
Data de publicació
2016-09-01
Volum
18
Número
18
Pàgina inicial
2387
Pàgina final
2398
DOI
https://doi.org/10.2217/nnm-2016-0200 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/100661 Obrir en finestra nova
URL
http://www.futuremedicine.com/doi/10.2217/nnm-2016-0200 Obrir en finestra nova
Activitat premiada
Si
Resum
Lactococcus lactis is a Gram-positive (endotoxin-free) food-grade bacteria exploited as alternative to Escherichia coli for recombinant protein production. We have explored here for the first time the ability of this platform as producer of complex, self-assembling protein materials. Materials & methods: Biophysical properties, cell penetrability and in vivo biodistribution upon systemic administration of tumor-targeted protein nanoparticles produced in L. lactis have been compared with the equi...
Citació
Cano, O., Cespedes, M., Unzueta, U., Roldan, M., Cubarsi, R., Vazquez, E., García, E., Villaverde, A. CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis. "Nanomedicine", 1 Setembre 2016, vol. 18, núm. 18, p. 2387-2398.
Paraules clau
protein nanoparticles, recombinant proteins, tumor-homing peptides
Grup de recerca
gAGE - Grup d'Astronomia i Geomatica

Participants

  • Cano Garrido, Olivia  (autor)
  • Céspedes, María Virtudes  (autor)
  • Unzueta, Ugutz  (autor)
  • Roldan, Monica  (autor)
  • Cubarsi Morera, Rafael  (autor)
  • Vazquez Gómez, Esther  (autor)
  • García Fruitós, Elena  (autor)
  • Villaverde Corrales, Antonio Pedro  (autor)

Arxius