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CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis

Author
Cano, O.; Céspedes, M. V.; Unzueta, U.; Roldan, M.; Cubarsi, R.; Vazquez, E.; García, E.; Villaverde, A.
Type of activity
Journal article
Journal
Nanomedicine
Date of publication
2016-09-01
Volume
18
Number
18
First page
2387
Last page
2398
DOI
https://doi.org/10.2217/nnm-2016-0200 Open in new window
Repository
http://hdl.handle.net/2117/100661 Open in new window
URL
http://www.futuremedicine.com/doi/10.2217/nnm-2016-0200 Open in new window
Rewarded activity
Yes
Abstract
Lactococcus lactis is a Gram-positive (endotoxin-free) food-grade bacteria exploited as alternative to Escherichia coli for recombinant protein production. We have explored here for the first time the ability of this platform as producer of complex, self-assembling protein materials. Materials & methods: Biophysical properties, cell penetrability and in vivo biodistribution upon systemic administration of tumor-targeted protein nanoparticles produced in L. lactis have been compared with the equi...
Citation
Cano, O., Cespedes, M., Unzueta, U., Roldan, M., Cubarsi, R., Vazquez, E., García, E., Villaverde, A. CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis. "Nanomedicine", 1 Setembre 2016, vol. 18, núm. 18, p. 2387-2398.
Keywords
protein nanoparticles, recombinant proteins, tumor-homing peptides
Group of research
gAGE - Research Group of Astronomy and Geomatics

Participants

  • Cano Garrido, Olivia  (author)
  • Céspedes, María Virtudes  (author)
  • Unzueta, Ugutz  (author)
  • Roldan, Monica  (author)
  • Cubarsi Morera, Rafael  (author)
  • Vazquez Gómez, Esther  (author)
  • García Fruitós, Elena  (author)
  • Villaverde Corrales, Antonio Pedro  (author)

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