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VNTR-DAT1 and COMTVal158Met genotypes modulate mental flexibility and adaptive behavior skills in Down syndrome

Author
del Hoyo, L.; Xicota, L.; Langohr, K.; Gonzalo Sanchez-Benavides; de Sola, S.; Cuenca, A.; Rodríguez, J.; Farré, M.; Dierssen, M.; De la Torre, R.
Type of activity
Journal article
Journal
Frontiers in Behavioral Neuroscience
Date of publication
2016-10-17
Volume
10
First page
1
Last page
9
DOI
https://doi.org/10.3389/fnbeh.2016.00193 Open in new window
Repository
http://hdl.handle.net/2117/99411 Open in new window
URL
http://journal.frontiersin.org/article/10.3389/fnbeh.2016.00193/full Open in new window
Abstract
Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC) deficits. DS also present a high risk for early onset of Alzheimer Disease-like dementia. The dopamine (DA) system plays a neuromodulatory role in the activity of the PFC. Several studies have implicated trait differences in DA...
Citation
del Hoyo, L., Xicota, L., Langohr, K., Sánchez Benavides, G., de Sola, S., Cuenca, A., Rodríguez, J., Farré, M., Dierssen, M., de la Torre, R. VNTR-DAT1 and COMTVal158Met genotypes modulate mental flexibility and adaptive behavior skills in Down syndrome. "Frontiers in Behavioral Neuroscience", 17 Octubre 2016, vol. 10, p. 1-9.
Keywords
COMTVal158Met, Down syndrome, PFC-dependent cognition, VNTR-DAT1, dopamine
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • del Hoyo, Laura  (author)
  • Xicota, Laura  (author)
  • Langohr, Klaus  (author)
  • Sánchez Benavides, Gonzalo  (author)
  • de Sola Llopis, Susana  (author)
  • Cuenca Royo, Aida  (author)
  • Rodríguez, Joan  (author)
  • Farré, Magí  (author)
  • Dierssen, Mara  (author)
  • De la Torre Fornell, Rafael  (author)

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