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Surface guidance of stem cell behavior: Chemically tailored co-presentation of integrin-binding peptides stimulates osteogenic differentiation in vitro and bone formation in vivo

Author
Fraioli, R.; Dashnyam, K.; Kim, J.; Perez, R.; Kim, H-W.; Gil, F.J.; Ginebra, M.P.; Manero, J.; Mas-Moruno, C.
Type of activity
Journal article
Journal
Acta biomaterialia
Date of publication
2016-10-01
Volume
43
First page
269
Last page
281
DOI
https://doi.org/10.1016/j.actbio.2016.07.049 Open in new window
Repository
http://hdl.handle.net/2117/100440 Open in new window
URL
http://www.sciencedirect.com/science/article/pii/S1742706116303841 Open in new window
Abstract
Surface modification stands out as a versatile technique to create instructive biomaterials that are able to actively direct stem cell fate. Chemical functionalization of titanium has been used in this work to stimulate the differentiation of human mesenchymal stem cells (hMSCs) into the osteoblastic lineage, by covalently anchoring a synthetic double-branched molecule (PTF) to the metal that allows a finely controlled presentation of peptidic motifs. In detail, the effect of the RGD adhesive pe...
Citation
Fraioli, R., Dashnyam, K., Kim, J., Perez, R.A., Kim, H-W., Gil, J., Ginebra, M.P., Manero, J., Mas-Moruno, C. Surface guidance of stem cell behavior: Chemically tailored co-presentation of integrin-binding peptides stimulates osteogenic differentiation in vitro and bone formation in vivo. "Acta biomaterialia", 1 Octubre 2016, vol. 43, p. 269-281.
Keywords
Integrin-binding peptides, Osseointegration, RGD-PHSRN, Titanium, hMSCs
Group of research
BBT - Biomaterials, Biomechanics and Tissue Engineering
CREB - Biomedical Engineering Research Centre
CRnE - Barcelona Research Center in Multiscale Science and Engineering

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