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Functionalization of CoCr surfaces with cell adhesive peptides to promote HUVECs adhesion and proliferation

Author
Castellanos, M.; Mas-Moruno, C.; Grau, A.; Serra-Picamal, X.; Trepat, Xavier; Albericio, F.; Joner, M.; Gil, F.J.; Ginebra, M.P.; Manero, J.; Pegueroles, Marta
Type of activity
Journal article
Journal
Applied surface science
Date of publication
2017-01-30
Volume
393
First page
82
Last page
92
DOI
https://doi.org/10.1016/j.apsusc.2016.09.107 Open in new window
Repository
http://hdl.handle.net/2117/102106 Open in new window
URL
http://www.sciencedirect.com/science/article/pii/S0169433216319857 Open in new window
Abstract
Biomimetic surface modification with peptides that have specific cell-binding moieties is a promising approach to improve endothelialization of metal-based stents. In this study, we functionalized CoCr surfaces with RGDS, REDV, YIGSR peptides and their combinations to promote endothelial cells (ECs) adhesion and proliferation. An extensive characterization of the functionalized surfaces was performed by XPS analysis, surface charge and quartz crystal microbalance with dissipation monitoring (QCM...
Citation
Castellanos, M., Mas-Moruno, C., Grau, A., Serra-Picamal, X., Trepat, Xavier, Albericio, F., Joner, M., Gil, J., Ginebra, M.P., Manero, J., Pegueroles, M. Functionalization of CoCr surfaces with cell adhesive peptides to promote HUVECs adhesion and proliferation. "Applied surface science", 30 Gener 2017, vol. 393, p. 82-92.
Keywords
Cell adhesive peptides, CoCr alloy, Endothelialization, HUVEC proliferation, SMCs adhesion, Surface functionalization
Group of research
BBT - Biomaterials, Biomechanics and Tissue Engineering
CREB - Biomedical Engineering Research Centre
CRnE - Barcelona Research Center in Multiscale Science and Engineering

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