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Biobased polymers for pharmaceutical applications: Self-assemblying bio-copolyesters and modified biopolymers

Total activity: 22
Type of activity
Competitive project
Acronym
BIOFARMPOL-I
Funding entity
MIN DE ECONOMIA Y COMPETITIVIDAD
Funding entity code
MAT2016-77345-C3-1-P
Amount
108.900,00 €
Start date
2016-12-30
End date
2019-06-29
Keywords
DDS, amphiphilic, anfifílicos, biodegradable, biodegradables, biopolymers, biopolímeros, copoliésteres, copolyesters, polielectrolitos, polimersomas, polipéptidos, polyelectrolytes, polymers, polymersomes, polypeptides, polímeros, sostenibles, sustainable
Abstract
This subproject BIOPHARMPOL I is part of the coordinated project "Bio-based polymers for pharmaceutical applications:
Advanced systems for delivery of therapeutic agents", and its objective is the preparation of bio-copolyesters
and modified biopolymers to be used for building such systems. The resulting products are sustainable, biodegradable and biocompatible,
and they contain functional groups that, by themselves or by further modification, make them sensitive to external stimuli. The execution of
the project embraces the synthesis of the new polymers, their chemical and structural characterization and their properties evaluation.
On one side, systems based on block copolyesters able to self-assemble in amphiphilic biphasic structures are prepared. The copolyesters
are synthesized by ring opening polymerization (ROP) of hydrophobic lactones initiated by hydrophilic telechelics. Both small size lactones
or dilactones and biobased macrolactones are used. The telechelics chosen are aliphatic polyesters derived from acetalized alditols or
aldaric acids as well as polypeptides made from acidic or basic bifunctional amino acids. The hydrophilic-lipophilic balance (HLB) is tuned
by proper selection of the building blocks or/and by adjusting the constitution of the mixtures used for copolymerization.
On the other side, amphiphilic systems are obtained by chemical modification of naturally-occurring polyacids (poly(gamma-glutamic acid)
and hyaluronic acid) by combining hydrophobization and functionalization. To this aim, click chemistry followed by orthogonal ROP of
hydrophobic lactones is applied and the ability of these systems to self-assemble in dense mnanoparticles or polymersomes is evaluated.
Also, the cross-linking of these polyacids with bifunctional labile segments based on hydrogen bonds or disulphide links is realized. The
objective in this case is to attain materials suitable for the design of hydrogel nanoparticles or excipients for control drug delivery. Another
last option is to carry out ionic coupling of the polyacids with ammonium or phosphonium organocations in order to generate stable
amphiphilic complexes suitable for the preparation of hydrogels with biocide properties.
The synthesis of the sugar-based monomers used in this project as well as the biodegradability evaluation work will be tasks overtaken by
Subproject-II. The measurement of specific properties of the systems addressed to drug delivery, and specifically their evaluation as
matrices for oral administration medicaments, will be made by Subproject III. Conversely, the studies on crystallinity and supramolecular
structure of all the systems created in the coordinated project will be carried out in the frame of this Subproject I. This project will also take
over the biocompatibility and biotoxicity evaluation work needed for the characterization of those systems of outstanding relevance; these
studies will be realized by the collaborating institutions with proved expertise in this type of essays.
Scope
Adm. Estat
Plan
Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016
Call year
2016
Funcding program
Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia
Funding subprogram
Subprograma Estatal de Generación de Conocimiento
Funding call
Excelencia: Proyectos I+D
Grant institution
Gobierno De España. Ministerio De Economía Y Competitividad, Mineco

Participants

Scientific and technological production

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