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Shape transformations of lipid bilayers following rapid cholesterol uptake

Autor
Rahimi, M.; Regan, D.; Arroyo, M.; Subramaniam, A.; Stone, H.; Staykova, M.
Tipus d'activitat
Article en revista
Revista
Biophysical journal
Data de publicació
2016
Volum
111
Número
12
Pàgina inicial
2651
Pàgina final
2657
DOI
https://doi.org/10.1016/j.bpj.2016.11.016 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/100123 Obrir en finestra nova
URL
http://www.cell.com/biophysj/abstract/S0006-3495(16)31045-1 Obrir en finestra nova
Resum
High cholesterol levels in the blood increase the risk of atherosclerosis. A common explanation is that the cholesterol increase in the plasma membrane perturbs the shape and functions of cells by disrupting the cell signaling pathways and the formation of membrane rafts. In this work, we show that after enhanced transient uptake of cholesterol, mono-component lipid bilayers change their shape similarly to cell membranes in vivo. The bilayers either expel lipid protrusions or spread laterally as...
Citació
Rahimi, M., Regan, D., Arroyo, M., Subramaniam, A., Stone, H., Staykova, M. Shape transformations of lipid bilayers following rapid cholesterol uptake. "Biophysical journal", 2016, vol. 111, núm. 12, p. 2651-2657.
Grup de recerca
LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria

Participants

  • Rahimi Lenji, Mohammad  (autor)
  • Regan, David  (autor)
  • Arroyo Balaguer, Marino  (autor)
  • Subramaniam, Anand Bala  (autor)
  • Stone, Howard A.  (autor)
  • Staykova, M  (autor)

Arxius