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Combined treatment with environmental enrichment and (-)-epigallocatechin-3-gallate ameliorates learning deficits and hippocampal alterations in a mouse model of Down Syndrome

Author
Catuara-Solarz, S.; Espinoa, J.; Erb, I.; Langohr, K.; González, J.; Notredame, C.; Dierssen, M.
Type of activity
Journal article
Journal
eNeuro
Date of publication
2016-11-08
Volume
3
Number
5
First page
1
Last page
18
DOI
https://doi.org/10.1523/ENEURO.0103-16.2016 Open in new window
Repository
http://hdl.handle.net/2117/102765 Open in new window
URL
http://www.eneuro.org/content/3/5/ENEURO.0103-16.2016 Open in new window
Abstract
Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, we have demonstrated beneficial effects of a combined treatment with green tea extract containing (-)-epigallocatechin-3-gallate (EGCG) and cognitive stimulation in young adult DS individuals. Although we could reproduce the cognitive-enhancing effects in mouse models, the underl...
Citation
Catuara-Solarz, S., Espinoa, J., Erb, I., Langohr, K., González, J., Notredame, C., Dierssen, M. Combined treatment with environmental enrichment and (-)-epigallocatechin-3-gallate ameliorates learning deficits and hippocampal alterations in a mouse model of Down Syndrome. "eNeuro", 8 Novembre 2016, vol. 3, núm. 5, p. 1-18.
Keywords
(-)-epigallocatechin-3-gallate, Environmental Enrichment, Excitation-Inhibition Imbalance, down Syndrome, neuroplasticity
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Catuara-Solarz, Silvina  (author)
  • Espinoa Carrasco, Jose  (author)
  • Erb, Ionas  (author)
  • Langohr, Klaus  (author)
  • González Ruiz, Juan Ramon  (author)
  • Notredame, Cedric  (author)
  • Dierssen, Mara  (author)

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