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Withdrawing inactive NRTIs in HIV-1 subjects with suppressed viraemia: a randomized trial

Author
Llibre, J.M.; Àlvarez, M.; Antela, A.; Toro, J.; Payeras, A.; Perez, M.J.; Imaz, A.; Masià, M.; Perez, N.; Burgos, J.; Clotet, B.
Type of activity
Journal article
Journal
Journal of antimicrobial chemotherapy
Date of publication
2016-04
Volume
71
Number
5
First page
1346
Last page
1351
DOI
https://doi.org/10.1093/jac/dkv461 Open in new window
Repository
http://hdl.handle.net/2117/104970 Open in new window
URL
https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkv461 Open in new window
Abstract
Extensively pretreated subjects with virological failure (VF) may receive salvage regimens containing NRTIs with only residual or no activity. Once virological suppression is achieved, their contribution remains elusive. This was a multicentre, randomized, prospective study. Subjects with at least one prior VF, HIV-1 RNA < 50 copies/mL for a parts per thousand yen6 months and receiving a regimen with at least two active drugs (one of them a boosted PI) were randomized 1:1 to stop (experimental...
Citation
Llibre, J.M., Àlvarez, M., Antela, A., Toro, J., Payeras, A., Perez, M.J., Imaz, A., Masià, M., Perez, N., Burgos, J., Clotet, B. Withdrawing inactive NRTIs in HIV-1 subjects with suppressed viraemia: a randomized trial. "Journal of antimicrobial chemotherapy", Abril 2016, vol. 71, núm. 5, p. 1346-1351.
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Llibre, Josep M.  (author)
  • Àlvarez Suau, Maria Hortènsia  (author)
  • Antela, Antonio  (author)
  • Toro, Jessica  (author)
  • Payeras, Antoni  (author)
  • Perez Elias, M. Jesus  (author)
  • Imaz, Arkaitz  (author)
  • Masià Canuto, Mar  (author)
  • Perez Alvarez, Nuria  (author)
  • Burgos, Joaquin  (author)
  • Clotet Sala, Bonaventura  (author)