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Clinical trial designs using CompARE. An on-line exploratory tool for investigators

Author
Gomez, M.; Gómez Melis, Guadalupe
Type of activity
Report
Date
2017-03
Code
Report DR 2017/1
Repository
http://hdl.handle.net/2117/104928 Open in new window
Abstract
Conclusions from randomized clinical trials (RCT) rely primarily on the primary endpoint (PE) chosen at the design stage of the study. There should generally be only one PE which should be able to provide the most clinically relevant and scientific evidence regarding the potential eficacy of the new treatment. Therefore, it is of utmost importance to select it appropriately. Composite endpoints, consisting of the union of several endpoints, are often used as PE in RCT. Gomez and Lagakos (2013) d...
Citation
Gomez, M., Gomez, G. "Clinical trial designs using CompARE. An on-line exploratory tool for investigators". 2017.
Keywords
Asymptotic relative efficiency, CompARE, composite endpoint, non-proportional hazards, sample size, web-based application.
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants