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Nanotransformation of vancomycin overcomes the intrinsic resistance of Gram-negative bacteria

Author
Fernandes, M.; Ivanova, K.; Hoyo, J.; Perez, S.; Francesko, A.; Tzanov, T.
Type of activity
Journal article
Journal
ACS applied materials and interfaces
Date of publication
2017-04-10
Volume
9
Number
17
First page
15022
Last page
15030
DOI
https://doi.org/10.1021/acsami.7b00217 Open in new window
Repository
http://hdl.handle.net/2117/103542 Open in new window
URL
http://pubs.acs.org/doi/abs/10.1021/acsami.7b00217 Open in new window
Abstract
The increased emergence of antibiotic-resistant bacteria is a growing public health concern, and although new drugs are constantly being sought, the pace of development is slow compared with the evolution and spread of multidrug- resistant species. In this study, we developed a novel broad-spectrum antimicrobial agent by simply transforming vancomycin into nanoform using sonochemistry. Vancomycin is a glycopeptide antibiotic largely used for the treatment of infections caused by Gram-positive ba...
Citation
Fernandes, M.M., Ivanova, K., Hoyo, J., Perez-Rafael, S., Francesko, A., Tzanov, T. Nanotransformation of vancomycin overcomes the intrinsic resistance of Gram-negative bacteria. "ACS applied materials and interfaces", 10 Abril 2017.
Keywords
Vancomycin, antibiotic nanospheres, antibiotic resistance, biofilms, sonochemistry
Group of research
GBMI - Molecular and Industrial Biotechnology Group

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