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Nonlinear signaling on biological networks: The role of stochasticity and spectral clustering

Autor
Hernadez-Hernandez, G.; Myers, J.; Alvarez-Lacalle, E.; Shiferaw, Y.
Tipus d'activitat
Article en revista
Revista
Physical review E
Data de publicació
2017-03-13
Volum
95
Número
3
DOI
https://doi.org/10.1103/PhysRevE.95.032313 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/104500 Obrir en finestra nova
URL
https://journals.aps.org/pre/abstract/10.1103/PhysRevE.95.032313 Obrir en finestra nova
Resum
Signal transduction within biological cells is governed by networks of interacting proteins. Communication between these proteins is mediated by signaling molecules which bind to receptors and induce stochastic transitions between different conformational states. Signaling is typically a cooperative process which requires the occurrence of multiple binding events so that reaction rates have a nonlinear dependence on the amount of signaling molecule. It is this nonlinearity that endows biological...
Citació
Hernadez-Hernandez, G., Myers, J., Alvarez-Lacalle, E., Shiferaw, Y. Nonlinear signaling on biological networks: The role of stochasticity and spectral clustering. "Physical review E", 13 Març 2017, vol. 95, núm. 3.
Grup de recerca
BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos

Participants

  • Hernadez Hernandez, Gonzalo  (autor)
  • Myers, Jesse  (autor)
  • Alvarez Lacalle, Enrique  (autor)
  • Shiferaw, Yohannes  (autor)

Arxius