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The anticipated odds ratios to decide the choice of a primary binary endpoint

Author
Bofill, M.; Gómez Melis, Guadalupe
Type of activity
Presentation of work at congresses
Name of edition
9th Conference of the Eastern Mediterranean Region of the International Biometric Society
Date of publication
2017
Presentation's date
2017-05
Book of congress proceedings
9th Conference of the Eastern Mediterranean Region and the Italian Region of the International Biometric Society (EMR-IBS): Thessaloniki, Greece: may 8-12, 2017: book of abstracts
First page
60
Last page
60
Abstract
Composite binary endpoints are widely chosen as primary endpoint in clinical trials. The use of composite endpoints entails diculties in the interpretation of the results since the composite eect might not re ect the eect of its components. We propose a methodology to quantify the gain in eciency of using the composite binary endpoint instead of its most relevant component as primary endpoint to lead the trial. The method, based on the Asymptotic Relative Eciency (ARE), depends on six parameters...
Keywords
Asymptotic Relative Eciency, Binary Endpoint, Clinical Trial, Composite Endpoint, Statistical Guidelines.
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants