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Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism

Author
Goday, A.; Farré, M.; Rodriguez, J.; Ramon, J.; Perez, C.; Papaseit, E.; Civit, E.; Langohr, K.; Li Carbo, M.; De la Torre, R.
Type of activity
Journal article
Journal
Obesity Surgery
Date of publication
2017-12
Volume
27
Number
12
First page
3194
Last page
3201
DOI
https://doi.org/10.1007/s11695-017-2745-z Open in new window
Repository
http://hdl.handle.net/2117/114078 Open in new window
URL
https://link.springer.com/article/10.1007%2Fs11695-017-2745-z Open in new window
Abstract
The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver function). In the present prospective study, we studied 24 morbid obese patients before, at 4 weeks, and 6 months after having undergone sleeve gastrectomy (n = 10) or Roux-en-Y gastric bypass (n = 14). For comparative purposes, 28 healthy controls (14 normal weights and 14 overweights) were ...
Citation
Goday, A., Farré, M., Rodriguez, J., Ramon, J., Perez, C., Papaseit, E., Civit, E., Langohr, K., Li Carbo, M., De la Torre, R. Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism. "Obesity Surgery", 30 Maig 2017, vol. 27, núm. 12, p. 3194-3201.
Keywords
Caffeine., Clinical trial, Gastric bypass, Metabolism paracetamol, Morbid obesity, Sleeve gastrectomy
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Goday Arno, Albert  (author)
  • Farré, Magí  (author)
  • Rodriguez Morato, Jose  (author)
  • Ramon, Jose Manuel  (author)
  • Perez Maña, Clara  (author)
  • Papaseit, Esther  (author)
  • Civit, Ester  (author)
  • Langohr, Klaus  (author)
  • Li Carbo, Marcel  (author)
  • De la Torre Fornell, Rafael  (author)

Attachments