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A bayesian test for Hardy-Weinberg equilibrium of bi-allelic X-chromosomal markers

Author
Puig, X.; Ginebra, J.; Graffelman, J.
Type of activity
Journal article
Journal
Heredity
Date of publication
2017-07
Number
119
First page
226
Last page
236
DOI
https://doi.org/10.1038/hdy.2017.30 Open in new window
Project funding
Grup de recerca en dades composicionals (RGCODA: Research group in compositional data)
Repository
http://hdl.handle.net/2117/110646 Open in new window
URL
http://www.nature.com/hdy/journal/vaop/ncurrent/full/hdy201730a.html?foxtrotcallback=true Open in new window
Abstract
The X chromosome is a relatively large chromosome, harboring a lot of genetic information. Much of the statistical analysis of X-chromosomal information is complicated by the fact that males only have one copy. Recently, frequentist statistical tests for Hardy–Weinberg equilibrium have been proposed specifically for dealing with markers on the X chromosome. Bayesian test procedures for Hardy–Weinberg equilibrium for the autosomes have been described, but Bayesian work on the X chromosome in ...
Citation
Puig, X., Ginebra, J., Graffelman, J. A bayesian test for Hardy-Weinberg equilibrium of bi-allelic X-chromosomal markers. "Heredity", Juliol 2017, núm. 119, p. 226-236.
Keywords
Bayesian model selection, Dirichlet prior, Hardy-Weinberg equilibrium, Inbreeding coeffcient, Posterior distribution, X-chromosome
Group of research
ADBD - Analysis of Complex Data for Business Decisions
COSDA-UPC - COmpositional and Spatial Data Analysis

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