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Role of PARP activity in lung cancer-induced cachexia: effects on muscle oxidative stress, proteolysis, anabolic markers, and phenotype

Author
Chacon, A.; Mateu Jimenez, M.; Langohr, K.; Fermoselle, C.; García Arumí, E.; Andreu, A.; Yelamos, J.; Barreiro, E.
Type of activity
Journal article
Journal
Journal of cellular physiology
Date of publication
2017-12
Volume
232
Number
12
First page
3744
Last page
3761
DOI
https://doi.org/10.1002/jcp.25851 Open in new window
Repository
http://hdl.handle.net/2117/114680 Open in new window
URL
http://onlinelibrary.wiley.com/doi/10.1002/jcp.25851/pdf Open in new window
Abstract
Strategies to treat cachexia are still at its infancy. Enhanced muscle protein breakdown and ubiquitin-proteasome system are common features of cachexia associated with chronic conditions including lung cancer (LC). Poly(ADP-ribose) polymerases (PARP), which play a major role in chromatin structure regulation, also underlie maintenance of muscle metabolism and body composition. We hypothesized that protein catabolism, proteolytic markers, muscle fiber phenotype, and muscle anabolism may improve ...
Citation
Chacon, A., Mateu Jimenez, M., Langohr, K., Fermoselle, C., García Arumí, E., Andreu, A., Yelamos, J., Barreiro, E. Role of PARP activity in lung cancer-induced cachexia: effects on muscle oxidative stress, proteolysis, anabolic markers, and phenotype. "Journal of cellular physiology", Desembre 2017, vol. 232, núm. 12, p. 3744-3761.
Keywords
PARP activity, Parp-1-/- and Parp-2-/- mice, cancer-induced cachexia, muscle anabolism and catabolism and mitochondrial content, muscle atrophy and myosin loss
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Chacon, Alba  (author)
  • Mateu Jimenez, Mercè  (author)
  • Langohr, Klaus  (author)
  • Fermoselle, Clara  (author)
  • García Arumí, Elena  (author)
  • Andreu Periz, Antonio L.  (author)
  • Yelamos, Jose  (author)
  • Barreiro Portela, Esther  (author)

Attachments