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Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast

Author
Millan, C.; Acosta-Reyes, F.J.; Lagartera, L.; Ebiloma, G.; Lemgruber, L.; Nué, J.; Saperas, N.; Dardonville, C.; De Koning, H.; Campos, J.Lourdes
Type of activity
Journal article
Journal
Nucleic acids research
Date of publication
2017-08-21
Volume
45
Number
14
First page
8378
Last page
8391
DOI
https://doi.org/10.1093/nar/gkx521 Open in new window
Repository
http://hdl.handle.net/2117/107671 Open in new window
URL
https://academic.oup.com/nar/article/45/14/8378/3868900/Functional-and-structural-analysis-of-ATspecific Open in new window
Abstract
Trypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pairs. This has prompted studies of drugs interacting with AT-rich DNA, such as the N-phenylbenzamide bis(2-aminoimidazoline) derivatives 1 [4-((4,5-dihydro-1H-imidazol-2-yl)amino)-N-(4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)benzamide dihydrochloride] and 2 [N-(3-chloro-4-((4,5-dihydro-1H-imidazol-2-yl)amino)p...
Citation
Millan, C., Acosta-Reyes, F.J., Lagartera, L., Ebiloma, G., Lemgruber, L., Nué, J., Saperas, N., Dardonville, C., De Koning, H., Campos, J. Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast. "Nucleic acids research", 21 Agost 2017, vol. 45, núm. 14, p. 8378-8391.
Keywords
cell cycle dna dna, kinetoplast trypanosoma brucei brucei mice kinetoplast crystal structure
Group of research
CEBIM - Molecular Biotechnology Centre
MACROM - Crystallography, Structure and Function of Biological Macromolecules

Participants

  • Millan Elias, Cinthia Raquel  (author)
  • Acosta Reyes, Francisco Javier  (author)
  • Lagartera, Laura  (author)
  • Ebiloma, Godwin U.  (author)
  • Lemgruber, Leandro  (author)
  • Nué Martinez, J. Jonathan  (author)
  • Saperas Plana, Nuria  (author)
  • Dardonville, Cristophe  (author)
  • De Koning, Harry Pieter  (author)
  • Campos Lopez, Josefa de Lourdes  (author)

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