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Identification of interleukin-27 (IL-27)/IL-27 receptor subunit alpha as a critical immune axis for in vivo hiv control

Author
Ruiz-Riol, M.; Berdnik, D.; Llano, A.; Mothe, B.; Gálvez, C.; Perez, S.; Oriol, B.; Olvera, A.; Silva, S.; Meulbroek, M.; Salvat-Pujol, F.; Coll, J.; Martínez, J.; Ganoza, C.; Sánchez, J.; Gómez Melis, Guadalupe; Coray, W.; Brander, C.
Type of activity
Journal article
Journal
Journal of virology
Date of publication
2017-08-01
Volume
91
Number
16
First page
1
Last page
13
DOI
https://doi.org/10.1128/JVI.00441-17 Open in new window
Repository
http://hdl.handle.net/2117/111542 Open in new window
URL
http://jvi.asm.org/content/91/16/e00441-17 Open in new window
Abstract
Intact and broad immune cell effector functions and specific individual cytokines have been linked to HIV disease outcome, but their relative contribution to HIV control remains unclear. We asked whether the proteome of secreted cytokines and signaling factors in peripheral blood can be used to discover specific pathways critical for host viral control. A custom glass-based microarray, able to measure >600 plasma proteins involved in cell-to-cell communication, was used to measure plasma protein...
Citation
Ruiz-Riol, M., Berdnik, D., Llano, A., Mothe, B., Gálvez, C., Pérez- Alvarez, S., Oriol, B., Olvera, A., Silva, S., Meulbroek, M., Salvat-Pujol, F., Coll, J., Martínez, J., Ganoza, C., Sánchez, J., Gomez, G., Coray, W., Brander, C. Identification of interleukin-27 (IL-27)/IL-27 receptor subunit alpha as a critical immune axis for in vivo hiv control. "Journal of virology", 1 Agost 2017, vol. 91, núm. 16, p. 1-13.
Keywords
HIV, HIV replication control, IL-27 cytokine, Th17 signaling, Wnt signaling, communicome, soluble communication factors
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Ruiz-Riol, M.  (author)
  • Berdnik, D.  (author)
  • Llano, A.  (author)
  • Mothe, Beatriz  (author)
  • Gálvez Barrón, César Pavel  (author)
  • Perez Alvarez, Susana  (author)
  • Oriol Tordera, B.  (author)
  • Olvera Van der Stoep, Alex  (author)
  • Silva Arrieta, S.  (author)
  • Meulbroek, M.  (author)
  • Salvat Pujol, Francesc  (author)
  • Coll, J.  (author)
  • Martínez Picado, Javier  (author)
  • Ganoza, Carmela  (author)
  • Sánchez, J.  (author)
  • Gomez Melis, Guadalupe  (author)
  • Coray, Wyss  (author)
  • Brander, Christian  (author)

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