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Intramolecular backbone center dot center dot center dot backbone hydrogen bonds in polypeptide conformations. The other way around: epsilon-turn

Author
Toniolo, C.; Crisma, M.; Formaggio, F.; Aleman, C.; Ramakrishnan, C.; Kalmanar, N.; Balaram, P.
Type of activity
Journal article
Journal
Biopolymers
Date of publication
2017-01-01
Volume
108
Number
1
DOI
https://doi.org/10.1002/bip.22911 Open in new window
Repository
http://hdl.handle.net/2117/108922 Open in new window
URL
http://onlinelibrary.wiley.com/doi/10.1002/bip.22911/abstract Open in new window
Abstract
In this study, we performed a detailed literature survey of the ¿-turn in peptides and proteins. This three-dimensional structural feature is characterized by an eleven-membered pseudo-cycle closed by an intramolecular backbone…backbone H-bond. Interestingly, in this motif the direction of the N-H…O¿=¿C H-bond runs opposite to that of the much more popular and extensively investigated a-, ß-, and ¿-turns. We did not authenticate unequivocally the ¿-turn main-chain reversal topology in ...
Citation
Toniolo, C., Crisma, M., Formaggio, F., Aleman, C., Ramakrishnan, C., Kalmanar, N., Balaram, P. Intramolecular backbone center dot center dot center dot backbone hydrogen bonds in polypeptide conformations. The other way around: epsilon-turn. "Biopolymers", 1 Gener 2017, vol. 108, núm. 1.
Keywords
NMR, X-ray diffraction, conformational energy calculations, peptide turns, solution conformation
Group of research
CRnE - Barcelona Research Center in Multiscale Science and Engineering
IMEM-BRT - Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

Participants

  • Toniolo, Claudio  (author)
  • Crisma, Marco  (author)
  • Formaggio, Fernando  (author)
  • Aleman Llanso, Carlos Enrique  (author)
  • Ramakrishnan, Chandrasekharan  (author)
  • Kalmanar, Neh  (author)
  • Balaram, Padmanabhan  (author)