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Minimal model for calcium alternans due to SR release refractoriness

Author
Rodriguez Cantalapiedra, I.; Alvarez-Lacalle, E.; Peñaranda, A.; Echebarria, B.
Type of activity
Journal article
Journal
Chaos : an interdisciplinary journal of nonlinear science
Date of publication
2017-09-07
Volume
27
Number
9
First page
093928-1
Last page
093928-13
DOI
https://doi.org/10.1063/1.5000709 Open in new window
Repository
http://hdl.handle.net/2117/108494 Open in new window
URL
http://aip.scitation.org/doi/10.1063/1.5000709 Open in new window
Abstract
In the heart, rapid pacing rates may induce alternations in the strength of cardiac contraction, termed pulsus alternans. Often, this is due to an instability in the dynamics of the intracellular calcium concentration, whose transients become larger and smaller at consecutive beats. This alternation has been linked experimentally and theoretically to two different mechanisms: an instability due to (1) a strong dependence of calcium release on sarcoplasmic reticulum (SR) load, together with a slo...
Citation
Rodriguez Cantalapiedra, I., Alvarez-Lacalle, E., Peñaranda, A., Echebarria, B. Minimal model for calcium alternans due to SR release refractoriness. "Chaos", 7 Setembre 2017, vol. 27, núm. 9, p. 093928-1-093928-13.
Keywords
Calcium alternans, Diseases and conditions, Ionic models, Phase transitions, Statistical mechanics models, Stochastic processes, Subcellular structures, Ventricular arrhythmias
Group of research
ANCORA - Anàlisi i control del ritme cardíac
BIOCOM-SC - Computational Biology and Complex Systems Group
GICITED - Interdisciplinary Group on Building Scienceand and Technology

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