Automatic segmentation of Z-lines in cardiac cells from microscope fluorescence images
Nolla-Colomer, C.; Vallmitjana, A.; Marchena, M.; Echebarria, B.; Herraiz, A.; Hove-Madsen, L.; Wayne Chen, S. R.; Benitez, R.
Type of activity
Presentation of work at congresses
Name of edition
39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Date of publication
Book of congress proceedings
EMBC'17: 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: July 11-15, 2017: International Convention Center (ICC), Jeju Island, Korea
We present an approach to quantify the spatial distribution of ryanodine receptors based on regional maxima segmentation and Z-lines segmentation using FFT and posterior clustering in mouse ventricular myocytes. The method provides an excellent performance under different settings, such as synthetic cell models and experimental conditions.