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Excessive activation of beta-2 adrenergic receptors induces arrhythmic calcium oscillations and ryanodine receptor phosphorylation at ser2809 but not at ser2815

Author
Jiménez-Sábado, V.; Nolla-Colomer, C.; Chun, G.; Sheng, H.; Tarifa, C.; Herraiz, A.; Vallmitjana, A.; Wayne Chen, S. R.; Benitez, R.; Tibbits, G.; Hove-Madsen, L.
Type of activity
Presentation of work at congresses
Name of edition
European Society of Cardiology Congress 2017
Date of publication
2017
Presentation's date
2017-05-16
Book of congress proceedings
European Heart Journal. ESC Congress 2017 26-30 August. Barcelona, Spain. Special edition. Volume 38, Suppl. 1 26 August 2017
First page
833
Last page
833
DOI
https://doi.org/10.1093/eurheartj/ehx504.P3999 Open in new window
URL
https://academic.oup.com/eurheartj/article/38/suppl_1/ehx504.P3999/4090241/P3999Excessive-activation-of-beta-2-adrenergic Open in new window
Abstract
Our findings suggest that prevention of PKA-dependent phosphorylation of the RyR2 at ser2809 may be a means to prevent arrhythmic calcium release induced by excessive beta-2 adrenergic stimulation.
Group of research
ANCORA - Anàlisi i control del ritme cardíac
B2SLab - Bioinformatics and Biomedical Signals Laboratory
CREB - Biomedical Engineering Research Centre

Participants

  • Jiménez Sábado, Verónica  (author and speaker )
  • Nolla Colomer, Carme  (author and speaker )
  • Chun, Grace  (author and speaker )
  • Sheng, Helen  (author and speaker )
  • Tarifa Lora, Carmen  (author and speaker )
  • Herraiz Martínez, Adela  (author and speaker )
  • Vallmitjana Lees, Alexander  (author and speaker )
  • Chen, S. R. Wayne  (author and speaker )
  • Benitez Iglesias, Raul  (author and speaker )
  • Tibbits, Glen  (author and speaker )
  • Hove-Madsen, Leif  (author and speaker )