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Spatial localization of ryanodine receptors in human cardiac cells

Author
Vallmitjana, A.; Nolla-Colomer, C.; Herraiz, A.; Hove-Madsen, L.; Benitez, R.
Type of activity
Presentation of work at congresses
Name of edition
37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Date of publication
2015
Presentation's date
2015-04-14
Book of congress proceedings
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015): Milan, Italy: 25-29 August 2015
First page
6297
Last page
6300
DOI
https://doi.org/10.1109/EMBC.2015.7319832 Open in new window
URL
http://ieeexplore.ieee.org/document/7319832/ Open in new window
Abstract
We present a novel image processing method to determine the location of ryanodine receptors in cardiac cells. A semi-automatic manual validation by an expert has been used in order to establish the performance of the segmentation method. The approach provides high accuracy under different experimental conditions and it is robust to common sources of noise including experimental, molecular and biological fluctuations.
Keywords
Biomedical monitoring, Biomembranes, Calcium, Detection algorithms, Fluorescence, Labeling, Robustness
Group of research
ANCORA - Anàlisi i control del ritme cardíac
B2SLab - Bioinformatics and Biomedical Signals Laboratory
CREB - Biomedical Engineering Research Centre

Participants

  • Vallmitjana Lees, Alexander  (author and speaker )
  • Nolla Colomer, Carme  (author and speaker )
  • Herraiz Martínez, Adela  (author and speaker )
  • Hove-Madsen, Leif  (author and speaker )
  • Benitez Iglesias, Raul  (author and speaker )