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Calcium alternans produced by increased sarcoplasmic reticulum refractoriness

Author
Rodriguez Cantalapiedra, I.; Lugo, C.A.; Peñaranda, A.; Echebarria, B.
Type of activity
Journal article
Journal
Computers in Cardiology
Date of publication
2011-09-29
Volume
38
First page
645
Last page
648
Repository
http://hdl.handle.net/2117/116131 Open in new window
URL
http://www.cinc.org/archives/2011/pdf/0645.pdf Open in new window
Abstract
Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this paper we want to study alternans that can be associated with alternations in the cytosolic calcium transient. To this end we study particularly, how a malfunction of Ryanodine Receptor (RyR) recovery time from in activation may induce beat-to-beat alternations in intracellular calcium concentration and how this could affect the stimulus propagation in inho...
Citation
Rodriguez Cantalapiedra, I., Lugo, C.A., Peñaranda, A., Echebarria, B. Calcium alternans produced by increased sarcoplasmic reticulum refractoriness. "Computers in Cardiology", 29 Setembre 2011, vol. 38, p. 645-648.
Keywords
Alternans, Ryanodine Receptor
Group of research
ANCORA - Anàlisi i control del ritme cardíac
BIOCOM-SC - Computational Biology and Complex Systems Group
GICITED - Interdisciplinary Group on Building Scienceand and Technology

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