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Selection of composite binary endpoints in clinical trials

Author
Bofill, M.; Gómez Melis, Guadalupe
Type of activity
Journal article
Journal
Biometrical journal
Date of publication
2018-03
Volume
60
Number
2
First page
246
Last page
261
DOI
https://doi.org/10.1002/bimj.201600229 Open in new window
Repository
http://hdl.handle.net/2117/114394 Open in new window
URL
http://onlinelibrary.wiley.com/doi/10.1002/bimj.201600229/abstract Open in new window
Abstract
The choice of a primary endpoint is an important issue when designing a clinical trial. It is common to use composite endpoints as a primary endpoint because it increases the number of observed events, captures more information and is expected to increase the power. However, combining events that have no similar clinical importance and have different treatment effects makes the interpretation of the results cumbersome and might reduce the power of the corresponding tests. Gómez and Lagakos prop...
Citation
Bofill, M., Gomez, G. Selection of composite binary endpoints in clinical trials. "Biometrical journal", 12 Octubre 2017.
Keywords
Asymptotic relative efficiency, Binary endpoint, Clinical trial, Composite endpoint, Treatment effects
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

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