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Sample size derivation for binary composite endpoints

Author
Bofill, M.; Gómez Melis, Guadalupe
Type of activity
Presentation of work at congresses
Name of edition
38th Annual Conference of the International Society for Clinical Biostatistics
Date of publication
2017
Presentation's date
2017-07-10
Book of congress proceedings
ISCB 2017: 38th Annual conference of the International Society for Clinical Biostatistics: Vigo, Spain: july 9-13, 2017: book of abstracts
First page
100
Last page
101
URL
http://www.iscb2017.info/uploadedFiles/ISCB2017.y23bw/fileManager/ISCB2017%20Book%20of%20Abstracts.pdf Open in new window
Abstract
Composite binary endpoints (CBE), defined as the union of several binary endpoints, are frequently used as the primary endpoint in a clinical trial. The specification of the treatment effect on the composite endpoint requires the information of their components and the degree of association between them. We summarize the treatment effect on the composite endpoint by means of the odds ratio and show that is determined by six parameters including the degree of association between components, the e...
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants