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Structural and Functional Studies of AT-Rich DNA Ligands and Their Effect on Trypanosoma brucei

Author
Millan, C.
Type of activity
Theses
Other related units
Department of Chemical Engineering
Defense's date
2017-10-27
URL
http://hdl.handle.net/2117/114006 Open in new window
Abstract
AT-rich sequences confer unique properties to DNA, such as high polymorphism and flexibility. The abundance of AT-rich DNA in several pathogens' genomes and the ability of specific molecules to selectively target AT base pairs have prompted studies on ligands that interact with the minor groove of high AT content DNA. Of special interest are kinetoplastid parasites, such as Trypanosoma brucei, the causative agent of sleeping sickness, which are distinguished by the presence of a very AT-rich mit...
Group of research
CEBIM - Molecular Biotechnology Centre
MACROM - Crystallography, Structure and Function of Biological Macromolecules
Citation
Millán Elías, C. R. "Structural and functional studies of AT-Rich DNA ligands and their effect on trypanosoma brucei". Tesi doctoral, UPC, Departament d'Enginyeria Química, 2017.

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