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Does evidence support the high expectations placed in precision medicine? A bibliographic review

Author
Cortes, J.; Gonzalez, J.; Medina, M.; Vogler, M.; Vilaro, M.; Elmore, M.; Senn, S.; Campbell, M.; Cobo, E.
Type of activity
Journal article
Journal
F1000 Research Ltd
Date of publication
2018-01-09
Volume
7
Number
30
First page
1
Last page
11
DOI
https://doi.org/10.12688/f1000research.13490.1 Open in new window
Repository
http://hdl.handle.net/2117/165517 Open in new window
URL
https://f1000research.com/articles/7-30/v1 Open in new window
Abstract
Background: Precision medicine is the Holy Grail of interventions that aretailored to a patient’s individual characteristics.  However, the conventional design of randomized trials assumes that each individual benefits by the same amount. Methods: We reviewed parallel trials with quantitative outcomes published in2004, 2007, 2010 and 2013. We collected baseline and final standard deviations of the main outcome. We assessed homoscedasticity...
Citation
Cortes, J. [et al.]. Does evidence support the high expectations placed in precision medicine? A bibliographic review. "F1000 Research Ltd", 9 Gener 2018, vol. 7, núm. 30, p. 1-11.
Keywords
Clinical Trial, Constant Effect, Homoscedasticity, Precision medicine, Review, Standard deviation, Variability
Group of research
GNOM - Mathematical Optimization Group
GRBIO - Biostatistics and Bioinformatics Research Group

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