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Calcium alternans is a global order-disorder phase transition: robustness on ryanodine receptor release dynamics

Author
Alvarez-Lacalle, E.; Peñaranda, A.; Rodriguez Cantalapiedra, I.; Shiferaw, Y.; Echebarria, B.
Type of activity
Journal article
Journal
Computing in Cardiology
Date of publication
2016-01-01
Volume
42
First page
329
Last page
332
Repository
http://hdl.handle.net/2117/116099 Open in new window
URL
http://www.cinc.org/archives/2015/pdf/0329.pdf Open in new window
Abstract
Electromechanical alternans is a beat-to-beat alterna- tion in the strength of contraction of a cardiac cell which appears often due to an instability of calcium cycling. The global calcium signal in cardiomyocytes is the result of the combined effect of several thousand micron scale domains called Calcium Release Units (CaRU), coupled through diffusion, where the flow of calcium among different cell compartments is regulated by stochastic signaling involv- ing the ryanodine receptor (RyR). Rece...
Citation
Alvarez-Lacalle, E., Peñaranda, A., Rodriguez Cantalapiedra, I., Shiferaw, Y., Echebarria, B. Calcium alternans is a global order-disorder phase transition: robustness on ryanodine receptor release dynamics. "Computing in Cardiology", 1 Gener 2016, vol. 42, p. 329-332.
Keywords
Calcium alternans Order-disorder phase transition Ryanodine Receptor
Group of research
ANCORA - Anàlisi i control del ritme cardíac
BIOCOM-SC - Computational Biology and Complex Systems Group
GICITED - Interdisciplinary Group on Building Scienceand and Technology

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