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Effect of RyR2 refractoriness and hypercalcemia on calcium overload, spontaneous release, and calcium alternans

Author
Alvarez-Lacalle, E.; Peñaranda, A.; Rodriguez Cantalapiedra, I.; Hove-Madsen, L.; Echebarria, B.
Type of activity
Journal article
Journal
Computing in Cardiology
Date of publication
2013
Volume
40
First page
683
Last page
686
Repository
http://hdl.handle.net/2117/116056 Open in new window
http://www.cinc.org/archives/2013/pdf/0683.pdf Open in new window
Abstract
In this work we use a computer model of a ventricular rabbit myocyte to study several factors that affect sarcoplasmic reticulum (SR) calcium load, such as hypercalcemia, SR calcium buffering, or ryanodine receptor (RyR2) dynamics. General conditions for the appearance of calcium spontaneous release in situations with calcium overload are obtained. Furthermore, we study the appearance of alternans under these conditions. The presence of calcium alternans may be due to either a steep calcium load...
Citation
Alvarez-Lacalle, E., Peñaranda, A., Rodriguez Cantalapiedra, I., Hove-Madsen, L., Echebarria, B. Effect of RyR2 refractoriness and hypercalcemia on calcium overload, spontaneous release, and calcium alternans. "Computing in Cardiology", 2013, vol. 40, p. 683-686.
Keywords
Calcium, Extracellular, Load modeling, Loading, Oscillators, Rabbits, Transient analysis, biochemistry, calcium, cellular transport, medical computing, medical disorders, molecular biophysics, muscle, physiological models
Group of research
ANCORA - Anàlisi i control del ritme cardíac
BIOCOM-SC - Computational Biology and Complex Systems Group
GICITED - Interdisciplinary Group on Building Scienceand and Technology

Participants