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Unravelling the effects of mechanical physiological conditioning on cardiac adipose tissue-derived progenitor cells in vitro and in silico

Author
Llucía, A.; Bragos, R.; Soler, C.; Roura, S.; Gálvez, C.; Cristina Prat-Vidal; Perea, I.; Bayés-Genis, A.
Type of activity
Journal article
Journal
Scientific reports
Date of publication
2018-01-11
Volume
8
Number
499
DOI
https://doi.org/10.1038/s41598-017-18799-5 Open in new window
Repository
http://hdl.handle.net/2117/113274 Open in new window
URL
https://www.nature.com/articles/s41598-017-18799-5 Open in new window
Abstract
Mechanical conditioning is incompletely characterized for stimulating therapeutic cells within the physiological range. We sought to unravel the mechanism of action underlying mechanical conditioning of adipose tissue-derived progenitor cells (ATDPCs), both in vitro and in silico. Cardiac ATDPCs, grown on 3 different patterned surfaces, were mechanically stretched for 7 days at 1 Hz. A custom-designed, magnet-based, mechanical stimulator device was developed to apply ~10% mechanical stretching t...
Citation
Llucía, A., Bragos, R., Soler, C., Roura, S., Gálvez, C., Cristina Prat-Vidal, Perea, I., Bayés-Genis, A. Unravelling the effects of mechanical physiological conditioning on cardiac adipose tissue-derived progenitor cells in vitro and in silico. "Scientific reports", 11 Gener 2018, vol. 8, núm. 499.
Keywords
Cardiology, Stem cells
Group of research
CREB - Biomedical Engineering Research Centre
IEB - Electronic and Biomedical Instrumentation

Participants

  • Llucía Valldeperas, Aida  (author)
  • Bragos Bardia, Ramon  (author)
  • Soler Botija, Carolina  (author)
  • Roura Ferrer, Santiago  (author)
  • Gálvez Montón, Carolina  (author)
  • Prat Vidal, Cristina  (author)
  • Perea Gil, Isaac  (author)
  • Bayés Genis, Antoni  (author)

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