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Coiled-coil conformation of a pentamidine-DNA complex

Author
Moreno, T.; Pous, J.; Subirana, J.; Campos, J.Lourdes
Type of activity
Journal article
Journal
Acta crystallographica. Section D, biological crystallography
Date of publication
2010-03
Volume
66
First page
251
Last page
257
DOI
https://doi.org/10.1107/S0907444909055693 Open in new window
Repository
http://hdl.handle.net/2117/8298 Open in new window
URL
http://www.ncbi.nlm.nih.gov/pubmed/20179336 Open in new window
Abstract
The coiled-coil structure formed by the complex of the DNA duplex d(ATATATATAT)2 with pentamidine is presented. The duplex was found to have a mixed structure containing Watson-Crick and Hoogsteen base pairs. The drug stabilizes the coiled coil through the formation of cross-links between neighbouring duplexes. The central part of the drug is found in the minor groove as expected, whereas the charged terminal amidine groups protrude and interact with phosphates from neighbouring molecules. The f...
Citation
Moreno, T. [et al.]. Coiled-coil conformation of a pentamidine-DNA complex. "Acta crystallographica. Section D, biological crystallography", Març 2010, vol. 66, p. 251-257.
Group of research
CEBIM - Molecular Biotechnology Centre
MACROM - Crystallography, Structure and Function of Biological Macromolecules

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