Loading...
Loading...

Go to the content (press return)

CD5L promotes M2 macrophage polarization through autophagy-mediated upregulation of ID3

Author
Sanjurjo, L.; Aran, G.; Téllez, É.; Amézaga, N.; Armengol, C.; Prats, C.; Lopez, D.; Sarrias, M.
Type of activity
Journal article
Journal
Frontiers in Immunology
Date of publication
2018-03-12
Volume
9
First page
1
Last page
16
DOI
https://doi.org/10.3389/fimmu.2018.00480 Open in new window
Repository
http://hdl.handle.net/2117/116217 Open in new window
URL
https://www.frontiersin.org/articles/10.3389/fimmu.2018.00480/full#h12 Open in new window
Abstract
CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer. In macrophages, CD5L promotes an anti-inflammatory cytokine profile in response to TLR activation. In the present study, we questioned whether CD5L is able to influence human macrophage plasticity, and drive its polarization toward any specific phenotype. We compared CD5L-induced phenotypic and functional changes...
Citation
Sanjurjo, L., Aran, G., Téllez, É., Amézaga, N., Armengol, C., Prats, C., Lopez, D., Sarrias, M. CD5L promotes M2 macrophage polarization through autophagy-mediated upregulation of ID3. "Frontiers in Immunology", 12 Març 2018, vol. 9, p. 1-16.
Keywords
autophagy, c D5 l, efferocytosis, i D3, macrophage polarization, mathematical algorithm, phagocytosis, scavenger receptor cysteine rich
Group of research
BIOCOM-SC - Computational Biology and Complex Systems Group

Participants

  • Sanjurjo, Lucía  (author)
  • Aran, Gemma  (author)
  • Téllez, Érica  (author)
  • Amézaga, Núria  (author)
  • Armengol, Carolina  (author)
  • Prats Soler, Clara  (author)
  • Lopez Codina, Daniel  (author)
  • Sarrias, Maria Rosa  (author)

Attachments