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A simplified implementation of the stationary liquid mass balance method for on-line OUR monitoring in animal cell cultures

Author
Fontova, A.; Lecina, M.; López, J.; Martínez-Monge, I.; Comas, P.; Bragos, R.; Cairó, J.
Type of activity
Journal article
Journal
Journal of chemical technology and biotechnology
Date of publication
2018-02-26
Volume
93
Number
6
First page
1757
Last page
1766
DOI
https://doi.org/10.1002/jctb.5551 Open in new window
Repository
http://hdl.handle.net/2117/115471 Open in new window
URL
https://onlinelibrary.wiley.com/doi/full/10.1002/jctb.5551 Open in new window
Abstract
BACKGROUND: Compared with other methods, the stationary liquid mass balance method for oxygen uptake rate (OUR) determination offers advantages in terms of estimation accuracy and reduction of stress. However, the need for sophisticated instrumentation, like mass flow controllers and gas analysers, has historically limited wider implementation of such a method. In this paper, a new simplified method based on inexpensive valves for the continuous estimation of OUR in animal cell cultures is evalu...
Citation
Fontova, A., Lecina, M., López, J., Martínez-Monge, I., Comas, P., Bragos, R., Cairó, J. A simplified implementation of the stationary liquid mass balance method for on-line OUR monitoring in animal cell cultures. "Journal of chemical technology and biotechnology", 26 Febrer 2018, vol. 93, núm. 6, p. 1757-1766
Keywords
Dissolved oxygen control, Liquid mass balance, OUR, On-line monitoring
Group of research
CREB - Biomedical Engineering Research Centre
IEB - Electronic and Biomedical Instrumentation

Participants

  • Fontova, Andreu  (author)
  • Lecina, Martí  (author)
  • López Repullo, Jonatan  (author)
  • Martínez Monge, Iván  (author)
  • Comas Sánchez, Pere  (author)
  • Bragos Bardia, Ramon  (author)
  • Cairó, Jordi Joan  (author)

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