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Development of ecofriendly cellulosic microdevices for immediate biodiagnosis

Total activity: 9
Type of activity
Competitive project
Acronym
MICROBIOCEL
Funding entity
AGENCIA ESTATAL DE INVESTIGACION
Funding entity code
CTQ2017-84966-C2-1-R
Amount
179.080,00 €
Start date
2018-01-01
End date
2020-12-31
Keywords
bacterial cellulose, biotechnology, biotecnología, celulosa bacteriana, diagnosis microdevices, enzimas, enzymes, microdispositivos de diagnosis, microelectrónica impresa, microfluidics, microfluídica, papel, paper, printed microelectronics
Abstract
Paper is a natural, renewable and biodegradable product which shows a high versatility, what makes it feasible the proposal of creating a
low cost and portable microdevice for immediate biodiagnosis. Besides, according to OMS these systems for health surveillance should
accomplish several criteria, several of which are not solved yet for their industrial application. The present projects plans the design of
several paper based components, that fulfil the different needs of analytical methods, and that could be integrated together to produce a
single 3D microdevice for biodiagnosis, showing multiple functionality adapted to each of the analysis purposes. For this objective there is
the need of new technologies (Biotechnology, Nanotechnology and Micro and Nanoelectronics). Microfluidics will allow the transport and
efficient mixing of the samples, while analysis response sensitivity will be enhanced by printed microelectronics.
More relevant aspects are: a) application of new enzymatic technologies for the modification and functionalization of cellulose; b) analysis
of biodegradability and life cycle of the microdevice; c) expand the incidence of the new device to countries under development and of low
income; d) great repercussion of the microdevice in health care systems; e) application of transversal technologies: advanced materials,
biotechnology, nanotechnology and micro and nanoelectronics
The proposed objectives are: 1) Identification and development of new cellulose modifying enzymes: lytic polysaccharide monooxigenases
(LPMO), expansins and new cellulases; 2) Hydrophobic functionalization of nanofibrilar cellulose (NFC) by enzyme technology; 3)
Designing of porous platforms from different cellulosic fibers to create a microfluidic circuit; 4) Application of bacterial cellulose (CB) in
paper products; 5) Production of cellulose hydrogels by sustainable methods; 6) Production of cellulosic support with surface smoothness
at nanoscale, and hydrophobic to print conducting inks and design electronic microcircuits; 7) Designing of sample transfer system among
different cellulosic supports; 8) Production of antioxidant oligosaccharides from hemicellulose; 9) Designing of optical and/or electronic
detection systems of immediate reading and easy interpretation, and personalized for the analysis aims; 10) Create a 3D biodiagnosis
microdevice that is robust, portable, easy to use and biodegradable; 11) Evaluate biodegradability and life cycle of the produced
microdevices
The expected results are: a) Identification and designing of new enzymes for the increase of paper mechanical properties; b) Designing of
cellulosic supports with different properties from the mixing of different cellulosic or nanocellulosic (vegetal or bacterial) sources; c)
Definition of the best combination of raw materials that allows the production of a cellulosic microfluidic platform with high efficiency for
liquid transport; d) Development of a device for highly sensitive electronic detection by printing of conducting inks; e) Production of a 3D
biodiagnosis device with multiple functionalities, robust, portable, biodegradable and easy to use, for immediate biodiagnosis from natural
and renewable resources.
Scope
Adm. Estat
Plan
Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016
Call year
2018
Funcding program
Programa Estatal de I+D+i Orientada a los Retos de la Sociedad
Funding call
Retos de Investigación: Proyectos de I+D+i
Grant institution
Agencia Estatal De Investigacion

Participants

Scientific and technological production

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