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The effects of death and post-mortem cold ischemia on human tissue transcriptomes

Author
Ferreira, P.; Muñoz, M.; Reverter Comes, Ferran
Type of activity
Journal article
Journal
Nature communications
Date of publication
2018-02-13
Volume
9
First page
1
Last page
15
DOI
https://doi.org/10.1038/s41467-017-02772-x Open in new window
Repository
http://hdl.handle.net/2117/115587 Open in new window
URL
https://www.nature.com/articles/s41467-017-02772-x Open in new window
Abstract
Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA levels. We investigate the impact of PMI on gene expression using data from multiple tissues of post-mortem donors obtained from the GTEx project. We find that many genes change expression over relatively short PMIs in a tissue-specific manner, but this potentially confounding ...
Citation
Ferreira, P., Muñoz, M., Reverter Comes, F. The effects of death and post-mortem cold ischemia on human tissue transcriptomes. "Nature communications", 13 Febrer 2018, vol. 9, p. 1-15.

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