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Supraspinal modulation of neuronal synchronization by nociceptive stimulation induces an enduring reorganization of dorsal horn neuronal connectivity

Author
Contreras-Hernández, E.; Chávez , D.; Hernández, E.; Bejar, J.; Martin, M.; Cortes, U.
Type of activity
Journal article
Journal
Journal of physiology-London
Date of publication
2018-05-01
Volume
596
Number
9
First page
1747
Last page
1776
DOI
https://doi.org/10.1113/JP275228 Open in new window
Repository
http://hdl.handle.net/2117/119170 Open in new window
URL
https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/JP275228 Open in new window
Abstract
Despite a profusion of information on the molecular and cellular mechanisms involved in the central sensitization produced by intense nociceptive stimulation, the changes in the patterns of functional connectivity between spinal neurones associated with the development of secondary hyperalgesia and allodynia remain largely unknown. Here we show that the state of central sensitization produced by the intradermal injection of capsaicin is associated with structured transformations in neuronal sync...
Citation
Contreras-Hernández, E., Chávez , D., Hernández, E., Béjar, J., Martin, M., Cortés, U. [et al.]. Supraspinal modulation of neuronal synchronization by nociceptive stimulation induces an enduring reorganization of dorsal horn neuronal connectivity. "Journal of physiology-London", 1 Maig 2018, vol. 596, núm. 9, p. 1747-1776.
Keywords
Analgesia, Capsaicin, Lidocaine, Nociception, Spinal cord
Group of research
IDEAI-UPC - Intelligent Data Science and Artificial Intelligence Research Center
KEMLG - Knowledge Engineering and Machine Learning Group

Participants

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