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Recent methodological developments for a Hardy-Weinberg analysis of X-chromosomal variants

Author
Graffelman, J.; Weir, B.; Ginebra, J.; Puig, X.
Type of activity
Presentation of work at congresses
Name of edition
International Biometric Conference
Date of publication
2018
Presentation's date
2018-07-12
Book of congress proceedings
Proceedings' Book IBC Barcelona 2018
First page
314
Last page
314
Abstract
Hardy-Weinberg equilibrium is a fundamental genetic principle, and assumed in many methods in statistical genetics. Genome-wide genetic studies typically test millions of genetic variants for equilibrium by exact test procedures, as part of a quality control procedure. X-chromosomal variants, for which males have only one copy, have hitherto been analysed by testing equilibrium in females only. This discards one third of the X chromosomes of the sample, and ignores the fact that equilibrium may ...
Group of research
ADBD - Analysis of Complex Data for Business Decisions
COSDA-UPC - COmpositional and Spatial Data Analysis

Participants