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The effect of cell morphology on the permeability of the nuclear envelope to diffusive factors

Author
Garcia, A.; Jacchetti, E.; Marotta, R.
Type of activity
Journal article
Journal
Frontiers in Physiology
Date of publication
2018-07
Volume
9
First page
1
Last page
15
DOI
https://doi.org/10.3389/fphys.2018.00925 Open in new window
Repository
http://hdl.handle.net/2117/120618 Open in new window
URL
https://www.frontiersin.org/articles/10.3389/fphys.2018.00925/full Open in new window
Abstract
A recent advance in understanding stem cell differentiation is that the cell is able to translate its morphology, i.e., roundish or spread, into a fate decision. We hypothesize that strain states in the nuclear envelope (NE) cause changes in the structure of the nuclear pore complexes. This induces significant changes in the NE’s permeability to the traffic of the transcription factors involved in stem cell differentiation which are imported into the nucleus by passive diffusion. To demonstrat...
Citation
Garcia, A., Jacchetti, E., Marotta, R. The effect of cell morphology on the permeability of the nuclear envelope to diffusive factors. "Frontiers in Physiology", Juliol 2018, vol. 9, p. 1-15.
Keywords
confocal microscopy, finite element modeling, nuclear envelope permeability, nuclear pore complex, passive diffusion, scanning transmission electron microscopy, stem cell differentiation
Group of research
LACÀN - Numerical Methods for Applied Sciences and Engineering

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