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Comblike ionic complexes of hyaluronic acid and alkanoylcholine surfactants as a platform for drug delivery systems

Author
Gamarra, A.; Muñoz, S.; Martinez de Ilarduya, A.; Thérien-Aubin, H.; Landfester, K.
Type of activity
Journal article
Journal
Biomacromolecules
Date of publication
2018-09-10
Volume
19
Number
9
First page
3669
Last page
3618
DOI
https://doi.org/10.1021/acs.biomac.8b00783 Open in new window
Project funding
Biobased polymers for pharmaceutical applications: Self-assemblying bio-copolyesters and modified biopolymers
Bioplásticos derivados de carbohidratos para envasado y farmacia. Subproyecto II.
Repository
http://hdl.handle.net/2117/121506 Open in new window
URL
https://pubs.acs.org/doi/10.1021/acs.biomac.8b00783 Open in new window
Abstract
Nontoxic alkanoylcholine soaps (nACh) were synthesized from choline and fatty acids with numbers of carbons n equal to 12, 14, 16, and 18, the latter including both saturated and 9-cis unsaturated alkanoyl chains. Coupling of nACh with hyaluronic acid (HyA) rendered comblike ionic complexes nACh·HyA that were non-water-soluble. The complexes were thermally stable up to temperatures above 200 °C but readily degraded by water, in particular when hyaluronidases were present in the aqueous medium....
Citation
Gamarra, A., Muñoz, S., Martinez de Ilarduya, A., Thérien-Aubin, H., Landfester, K. Comblike ionic complexes of hyaluronic acid and alkanoylcholine surfactants as a platform for drug delivery systems. "Biomacromolecules", 10 Setembre 2018, vol. 19, núm. 9, p. 3669-3618.
Keywords
Choline esters, Complexes, Drug deliver systems, Hyaluronic Acid, Nanoparticles
Group of research
POL - Advanced Industrial Polymers and Technological Biopolymers

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